A piece of music, you know, can make you fed up (6)
I believe the answer is:
sicken
'make you fed up' is the definition.
I can't tell whether this defines the answer.
'a piece of music you know' is the wordplay.
'a piece of music you' becomes 'sic' (I can't justify this - if you can you should give a lot more credence to this answer).
'know' becomes 'ken' (Scottish term meaning to know).
'sic'+'ken'='SICKEN'
'can' acts as a link.
Can you help me to learn more?
(Other definitions for sicken that I've seen before include "Become unwell" , "Become ill" , "Make ill or nauseate" , "Make ill or totally disgust" .)