Affecting the whole body (8)
I believe the answer is:
systemic
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">affecting the whole body</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for systemic that I've seen before include "Relating to a complex whole" , "Relating to the whole organism" , "City mess (anag)" , "Affecting a body, institution, etc as a whole" , "insecticide" .)