Affectionate female working with Director (4)
I believe the answer is:
fond
'affectionate' is the definition.
(synonyms)
'female working with director' is the wordplay.
'female' becomes 'f' (abbreviation).
'working' becomes 'on' (e.g. a machine is working or on).
'with' is a charade indicator (letters next to each other).
'director' becomes 'd' (abbreviation eg in film reviews).
'f'+'on'+'d'='FOND'
(Other definitions for fond that I've seen before include "Affectionate - tender" , "Affectionate, maybe foolish" , "Feeling affection, maybe foolish" , "Partial to" , "Keen on; indulgent" .)