Again, rhyme with "defeat" (7)
I believe the answer is:
reverse
'defeat' is the definition.
(reverse is a kind of defeat)
'again rhyme' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'rhyme' becomes 'verse' (synonyms).
're'+'verse'='REVERSE'
'with' is the link.
(Other definitions for reverse that I've seen before include "Upset" , "Tails (of a coin)" , "Turn inside out or upside down" , "Countermand" , "Move backwards" .)