___ and Old Lace, 1944 comedy directed by Frank Capra (7)

I believe the answer is:

arsenic

(Other definitions for arsenic that I've seen before include "Toxic metalloid element" , "-- and Old Lace (play)" , "Can rise result from poison?" , "Toxic metallic element used as rat poison" , "Ratsbane" .)

I've seen this clue in The Guardian.

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