Anger on stage in a cast (10)
I believe the answer is:
antagonise
'anger' is the definition.
(I've seen this before)
'on stage in a cast' is the wordplay.
'cast' is an anagram indicator (letters are dispersed or cast around).
'on'+'stage'+'in'+'a'='onstageina'
'onstageina' anagrammed gives 'ANTAGONISE'.
(Other definitions for antagonise that I've seen before include "Provoke hostility" , "Get on the wrong side of" , "Create hostility" , "Bug" , "Make an enemy of" .)