Angry with a charge at the medical centre (5)
I believe the answer is:
irate
'angry' is the definition.
(irate can mean angry or annoyed)
'charge at the medical centre' is the wordplay.
'charge' becomes 'rate' (rate is a kind of charge).
'at' says to put letters next to each other (I've seen this in other clues).
'centre' indicates the central letters.
The central letter of 'medical' is 'i'.
'rate' put after 'i' is 'IRATE'.
'with a' acts as a link.
(Other definitions for irate that I've seen before include "Annoyed, irritated" , "Wrathful" , "Annoyed, nettled" , "Indignant, angry" , "ranting" .)