Blame Bill, copper? Snide, beginning and end (6)
I believe the answer is:
accuse
'blame' is the definition.
(I've seen this before)
'bill copper? snide beginning and end' is the wordplay.
'bill' becomes 'ac' (short for account).
'copper?' becomes 'Cu' (chemical symbol).
'beginning and end' suggests removing the centre.
'snide' with its middle removed is 'se'.
'ac'+'cu'+'se'='ACCUSE'
(Other definitions for accuse that I've seen before include "Indict, blame wrongdoing on" , "Level a charge against" , "Charge with, lay blame on" , "Lay blame or allege guilt" , "Charge (someone) with an offence" .)