Blasphemy? I’m a matter for regret around Close in Carlisle (7)
I believe the answer is:
impiety
'blasphemy?' is the definition.
(thesaurus)
'i'm a matter for regret around close in carlisle' is the wordplay.
'a matter for regret' becomes 'pity' (a pity is a shame or regrettable outcome).
'around' is an insertion indicator.
'close in' says to take the final letters.
The last letter of 'carlisle' is 'e'.
'pity' enclosing 'e' is 'piety'.
'im'+'piety'='IMPIETY'
(Other definitions for impiety that I've seen before include "sacrilege" , "Irreligion" , "godlessness" , "Irreverence, profanity" , "Lack of reverence" .)