Charming American uplifted by welcome (5)
I believe the answer is:
suave
'charming' is the definition.
(I've seen this in another clue)
'american uplifted by welcome' is the wordplay.
'american' becomes 'US' (abbreviation for United States).
'uplifted' says the letters should be written in reverse.
'by' means one lot of letters go next to another.
'welcome' becomes 'ave' ('ave' is a Latin greeting).
'us' back-to-front is 'su'.
'su'+'ave'='SUAVE'
(Other definitions for suave that I've seen before include "Urbane and sophisticated" , "Charming, confident" , "Smoothly sophisticated" , "Svelte" , "Debonair" .)