Cheat twits cleverly (5)
I believe the answer is:
twist
'cheat' is the definition.
(I've seen this before)
'twits cleverly' is the wordplay.
'cleverly' indicates anagramming the letters (a clever or tricky version of the letters).
'twits' is an anagram of 'TWIST'.
(Other definitions for twist that I've seen before include "Wring" , "dance from the 60s" , "Embellishment to plot" , "Unexpected development of events" , "Convolute" .)