Comes to again and feels pain (7)
I believe the answer is:
reaches
'comes to' is the definition.
(I've seen this before)
'again and feels pain' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'and' means one lot of letters go next to another.
'feels pain' becomes 'aches' (I've seen this in another clue).
're'+'aches'='REACHES'
(Other definitions for reaches that I've seen before include "Succeeds in achieving" , "Hands down" , "River stretches between bends" , "Arrives at" , "Bays" .)