Depend on a soft-hearted response (5)
I believe the answer is:
reply
'hearted response' is the definition.
'reply' can be an answer for 'response' (synonyms). I'm not certain of the 'hearted' bit.
'depend on a soft' is the wordplay.
'depend' becomes 'rely' (to depend on someone is to rely on them).
'on' is an insertion indicator (as in clothing 'on' a person).
'a soft' becomes 'p' (musical abbreviation for 'piano', soft).
'rely' enclosing 'p' is 'REPLY'.
Can you help me to learn more?
(Other definitions for reply that I've seen before include "Answer, respond" , "Comeback" , "Return" , "response is demanded" , "counterattack?" .)