Despite everything (10)
I believe the answer is:
regardless
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">despite everything</span>' is the definition.<br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for regardless that I've seen before include "Heeding no one - one of the 14 films" , "Lacking consideration" , "Indifferent - come what may" , "Whatever happens" , "Without heed" .)