Doctor Galen with niece: not Grace? (10)
I believe the answer is:
inelegance
'grace?' is the definition.
The answer and definition can be both human attributes as well as being singular nouns.
Maybe there's a link between them I don't understand?
'doctor galen with niece' is the wordplay.
'doctor' indicates an anagram.
'with' is a charade indicator (letters next to each other).
'galen'+'niece'='galenniece'
'galenniece' is an anagram of 'INELEGANCE'.
'not' acts as a link.
Can you help me to learn more?
(Another definition for inelegance that I've seen is " Lack of refinement".)