Doctor Galen with niece: not Grace? (10)

I believe the answer is:

inelegance

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'grace?' is the definition.
The definition and answer can be both human attributes as well as being singular nouns.
Perhaps they are linked in a way I don't understand?

'doctor galen with niece' is the wordplay.
'doctor' indicates anagramming the letters.
'with' means one lot of letters go next to another.
'galen' after 'niece' is 'niecegalen'.
'niecegalen' anagrammed gives 'INELEGANCE'.

'not' is the link.

Can you help me to learn more?

(Another definition for inelegance that I've seen is " Lack of refinement".)

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