Drive Cleo crazy about a politician! (6)
I believe the answer is:
compel
'drive' is the definition.
(I've seen this in another clue)
'cleo crazy about a politician' is the wordplay.
'crazy' is an anagram indicator.
'about' means one lot of letters goes inside another.
'a politician' becomes 'MP' (Member of Parliament).
'cleo' anagrammed gives 'coel'.
'coel' placed around 'mp' is 'COMPEL'.
(Other definitions for compel that I've seen before include "Use force or influence to make person do something" , "'Force, oblige (6)'" , "Use force, oblige" , "Make someone do something" , "Bring about by force" .)