Drug in complicated operation (4)
I believe the answer is:
dope
'drug' is the definition.
(colloquial)
'in complicated operation' is the wordplay.
'in' indicates the answer is hidden within the clue.
'DOPE' is hidden within 'complicated operation'.
(Other definitions for dope that I've seen before include "Marijuana - fool" , "Inside information (slang)" , "Fool - cannabis" , "Booby" , "Drugs for a dimwit" .)