Estrangement (10)
I believe the answer is:
alienation
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">estrangement</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for alienation that I've seen before include "Isolation" , "Estrangement" , "the effect of Brecht" , "Brecht's effect" , "Turning" .)