Exasperated by a useless railway! (5)
I believe the answer is:
angry
'exasperated' is the definition.
(thesaurus)
'by a useless railway' is the wordplay.
'by' means one lot of letters go next to another.
'a useless' becomes 'ang' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'railway' becomes 'ry' (abbreviation).
'ang' next to 'ry' is 'ANGRY'.
Can you help me to learn more?
(Other definitions for angry that I've seen before include "Inflamed" , "Vexed" , "Very annoyed" , "Irate, mad" , "Incensed" .)