Extreme anxiety (8)
I believe the answer is:
distress
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">extreme anxiety</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for distress that I've seen before include "Such a signal indicates trouble" , "Suffering, worry" , "Upset" , "grief" , "Severe pain" .)