Extreme pain or misery (7)
I believe the answer is:
anguish
<span class="explanation-format__ClueExplanation">I believe this clue is a double definition.<br/ ><br/ >'<span class="explanation-format__original">extreme pain</span>' is the first definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >'<span class="explanation-format__original">misery</span>' is the second definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ ></span>
(Other definitions for anguish that I've seen before include "Extreme misery" , "Great (mental) pain" , "Great suffering" , "Grief" , "Severe pain, may be mental" .)