First lady (3)
I believe the answer is:
eve
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">first lady</span>' is the definition.<br/ ><span class="explanation-format__explanation">(first woman in the Bible)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for eve that I've seen before include "Previous day" , "Girl" , "See 13 Across" , "First lady from the night before" , "Lady of the previous night" .)