Further from Rome (4)
I believe the answer is:
more
'further' is the definition.
(synonyms)
'from rome?' is the wordplay.
'from' indicates anagramming the letters (the anagram comes from the same letters).
'rome' anagrammed gives 'MORE'.
(Other definitions for more that I've seen before include "To a greater extent" , "Greater quantity or number" , "A greater amount" , "See 9" , "victim of Henry" .)