Go very quietly out East (3)
I believe the answer is:
pep
'go' is the definition.
(both can mean energy or vitality)
'quietly out east' is the wordplay.
'quietly' becomes 'pp' (musical abbreviation for pianissimo).
'out' indicates putting letters inside.
'east' becomes 'e' (abbreviation).
'pp' placed around 'e' is 'PEP'.
'very' is the link.
(Other definitions for pep that I've seen before include "Energy, zip" , "Energy or enthusiasm" , "Palindromic vim and vigour" , "Go" , "Energy, liveliness" .)