Great annoyance (5)
I believe the answer is:
anger
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">great annoyance</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for anger that I've seen before include "Strong displeasure" , "Incense" , "wind up?" , "Hostile feeling" , "Strongly annoy" .)