He's disturbed by the female (3)
I believe the answer is:
she
'female' is the definition.
('she' refers to a woman)
'he's disturbed' is the wordplay.
'disturbed' is an anagram indicator (the order of letters is disturbed).
'hes' anagrammed gives 'SHE'.
'by the' is the link.
(Other definitions for she that I've seen before include "way to refer to mare" , "That woman" , "1887 Rider Haggard novel" , "The one who must be obeyed" , "Female person" .)