Huge local inn manufactured mind-altering substance (12)
I believe the answer is:
hallucinogen
'mind-altering substance' is the definition.
Although both the answer and definition are singular nouns, I cannot see how one could define the other.
'huge local inn manufactured' is the wordplay.
'manufactured' indicates anagramming the letters.
'huge'+'local'+'inn'='hugelocalinn'
'hugelocalinn' is an anagram of 'HALLUCINOGEN'.
Can you help me to learn more?
(Other definitions for hallucinogen that I've seen before include "Trip-inducing substance" , "Mind-altering drug" , "Mind-bending drug" , "mind-blowing" , "Drug inducing unreal perceptions" .)