Informs one about every setback (7)
I believe the answer is:
teaches
'informs' is the definition.
(teaching is a kind of informing)
'one about every setback' is the wordplay.
'one about' means one lot of letters goes inside another.
'every' becomes 'each' (synonyms).
'setback' becomes 'tes' (I've seen this in other clues).
'each' inserted inside 'tes' is 'TEACHES'.
(Other definitions for teaches that I've seen before include "Trains" , "Instructs" .)