Intense dislike of tangled thread (6)
I believe the answer is:
hatred
'intense dislike' is the definition.
(I've seen this before)
'tangled thread' is the wordplay.
'tangled' indicates an anagram.
'thread' is an anagram of 'HATRED'.
'of' is the link.
(Other definitions for hatred that I've seen before include "Deep dislike and aversion" , "Abhorrence, detestation" , "Dearth (anag)" , "Intense dislike" , "Extreme dislike and enmity" .)