Irritate with hypodermic (6)
I believe the answer is:
needle
This could be a double definition.
'irritate' is the first definition.
(I've seen this before)
'hypodermic' is the second definition.
The answer and definition can be both man-made objects as well as being singular nouns.
Maybe there's an association between them I don't understand?
'with' acts as a link.
Can you help me to learn more?
(Other definitions for needle that I've seen before include "Instrument to annoy" , "It's difficult to find one in a haystack" , "Annoy, tantalise" , "Thin pointer; antagonise" , "Implement for knitting and sewing" .)