Italian city an ego destroyed (5)
I believe the answer is:
genoa
'italian city' is the definition.
(I've seen this before)
'an ego destroyed' is the wordplay.
'destroyed' is an anagram indicator.
'an'+'ego'='anego'
'anego' anagrammed gives 'GENOA'.
(Other definitions for genoa that I've seen before include "City of Italy" , "Italian city has no age, oddly" , "North Italian port" , "Type of rich fruit cake" , "Seaport in northwestern Italy" .)