Lackey of orange crackpot seen in Houston on vacation (6-2)
I believe the answer is:
hanger-on
'lackey' is the definition.
(thesaurus)
'orange crackpot seen in houston on vacation' is the wordplay.
'crackpot' indicates anagramming the letters (an eccentric ordering of the letters).
'seen in' indicates putting letters inside.
'on vacation' says to hollow out the word (remove centre letters) (after the inside letters have vacated the word).
'houston' with its centre taken out is 'hn'.
'orange' with letters rearranged gives 'angero'.
'angero' put inside 'hn' is 'HANGER-ON'.
'of' acts as a link.
(Other definitions for hanger-on that I've seen before include "A sycophant - he really clings" , "Social leech" , "Persistent follower" , "Sycophantic associate" , "Unwanted follower or dependant, parasite" .)