Lame sort of gender (4)
I believe the answer is:
male
'gender' is the definition.
(I have seen 'A gender ' mean 'male' so perhaps 'gender' could also mean 'male')
'lame sort' is the wordplay.
'sort' indicates anagramming the letters.
'lame' with letters rearranged gives 'MALE'.
'of' is the link.
(Other definitions for male that I've seen before include "A gender" , "As are drakes, bulls etc." , "One cannot have babies" , "Maldives capital; masculine" , "Lame sort of fellow" .)