Lay off child who was Home Alone in busy city (5)
I believe the answer is:
macau
'lay off child who was home alone in busy city' is the definition.
The definition suggests a singular noun which matches the answer.
This is all the clue.
Can you help me to learn more?
(Other definitions for macau that I've seen before include "somewhere in China" , "Small peninsula in China, a Portuguese territory until 1999" , "region of China" , "Part of China" , "SW of 24 [SHANGHAI]" .)