Make a difference (6)
I believe the answer is:
matter
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">make a difference</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for matter that I've seen before include "See 10" , "It has mass and occupies space" , "Be of significance" , "See 18" , "Concern" .)