Many can take a rise out of this penny-pincher (5)
I believe the answer is:
miser
'this penny-pincher' is the definition.
(I've seen this in another clue)
'many can take a rise out' is the wordplay.
'many can take' becomes 'm' (I can't justify this - if you can you should believe this answer much more).
'out' is an anagram indicator (out can mean wrong or inaccurate).
'rise' is an anagram of 'iser'.
'm'+'iser'='MISER'
'of' is the link.
Can you help me to learn more?
(Other definitions for miser that I've seen before include "Person who hoards money" , "Cheapskate" , "Tightwad, hoarder" , "Penny-pincher" , "Mean individual" .)