Nervous European Democrat generally cleared out (4)
I believe the answer is:
edgy
'nervous' is the definition.
(synonyms)
'european democrat generally cleared out' is the wordplay.
'european' becomes 'E' (abbreviation e.g. EU).
'democrat' becomes 'd'.
'cleared out' suggests removing the centre.
'generally' with its centre removed is 'gy'.
'e'+'d'+'gy'='EDGY'
(Other definitions for edgy that I've seen before include "Sharp in outline" , "Challengingly experimental" , "In a tense state" , "Apprehensive" , "Red shade" .)