Oxford college that is in the care of old hands? (5)
I believe the answer is:
oriel
'oxford college' is the definition.
(Oriel College, Oxford)
'that is in the care of old hands?' is the wordplay.
I cannot really understand how this works, but
'of' could be 'o' and 'o' is present in the answer.
'that is' could be 'ie' (short for Latin 'id est', 'that is') and 'ie' is found in the answer.
'hands?' could be 'rl' (abbreviations for left and right) and 'rl' is located in the leftover letters.
No letters remain.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for oriel that I've seen before include "Oxford college, founded 1326" , "Upper room window" , "Style of window" , "Loire (anag.)" , "corbelled window?" .)