Profitable forging Vermeer at uni (12)
I believe the answer is:
remunerative
'profitable' is the definition.
(similar in meaning)
'forging vermeer at uni' is the wordplay.
'forging' indicates an anagram (I've seen this in other clues).
'vermeer'+'at'+'uni'='vermeeratuni'
'vermeeratuni' with letters rearranged gives 'REMUNERATIVE'.
(Other definitions for remunerative that I've seen before include "(Of work) paying" , "Profitable" .)