Resident at home with a friend (6)
I believe the answer is:
inmate
'resident' is the definition.
(inmate is a kind of resident)
'home with a friend' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'with' means one lot of letters go next to another.
'a friend' becomes 'mate' (mate is a kind of friend).
'in'+'mate'='INMATE'
'at' is the link.
(Other definitions for inmate that I've seen before include "One is in jail" , "Inhabitant of prison or hospital" , "One held in prison" , "Inhabitant of prison or other institution" , "One is confined to an institution" .)