Scruple (5)
I believe the answer is:
qualm
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">scruple</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for qualm that I've seen before include "Misgiving, pang of conscience" , "Anxiety" , "Sudden feeling of unease or misgiving" , "Uneasiness, doubt" , "Uneasy feeling" .)