Sign of fresh air to the east and south (5)
I believe the answer is:
aries
'sign' is the definition.
(star sign)
'fresh air to the east and south' is the wordplay.
'fresh' is an anagram indicator (a fresh re-ordering of the letters).
'to' says to put letters next to each other (I've seen this in other clues).
'the east' becomes 'E' (abbreviation).
'and' means one lot of letters go next to another.
'south' becomes 's' (abbreviation).
'air' after 'e' is 'eair'.
'eair' is an anagram of 'arie'.
'arie'+'s'='ARIES'
'of' is the link.
(Other definitions for aries that I've seen before include "star group" , "Zodiacal sign also known as the Ram" , "Sheep" , "Stars" , "A sign from Heaven" .)