Sleeps around, initially eschewing drug (5)
I believe the answer is:
spike
'drug' is the definition.
(thesaurus)
'sleeps around initially eschewing' is the wordplay.
'sleeps' becomes 'kips' ('kip' can be a synonym of 'sleep').
'around' shows that the letters should be reversed in order.
'initially' says to take the initial letters.
The first letter of 'eschewing' is 'e'.
'kips' written backwards gives 'spik'.
'spik'+'e'='SPIKE'
(Other definitions for spike that I've seen before include "comedian of old" , "Large nail; lace (drink)" , "Frustrate" , "Sharp point; flower cluster" , "Prong" .)