Substance, general meaning (4)
I believe the answer is:
gist
<span class="explanation-format__ClueExplanation">This clue is a double definition.<br/ ><br/ >'<span class="explanation-format__original">substance</span>' is the first definition.<br/ ><span class="explanation-format__explanation">(I know that substance can be written as gist)</span><br/ ><br/ >'<span class="explanation-format__original">general meaning</span>' is the second definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ ></span>
(Other definitions for gist that I've seen before include "Essence; meaning" , "The substance of a text" , "Essential point or meaning of, say, the matter" , "Main idea, kernel of matter" , "Drift" .)