Suffering US heading for transformation (9)
I believe the answer is:
anguished
'suffering' is the definition.
(synonyms)
'us heading for transformation' is the wordplay.
'for transformation' indicates an anagram (I've seen this in other clues).
'us'+'heading'='usheading'
'usheading' with letters rearranged gives 'ANGUISHED'.
(Other definitions for anguished that I've seen before include "Suffering greatly" , "Dolorous" , "Distressed mentally" .)