They help evacuate nurse and English old ladies (6)
I believe the answer is:
enemas
'they help evacuate' is the definition.
The definition suggests an adverb but the answer is not.
'nurse and english old ladies' is the wordplay.
'nurse' becomes 'EN' (abbreviation for state-enrolled nurse).
'and' means one lot of letters go next to another.
'english' becomes 'E' (abbreviation).
'old ladies' becomes 'mas' (I am not sure about this - if you are sure you should believe this answer much more).
'en'+'e'+'mas'='ENEMAS'
Can you help me to learn more?
(Other definitions for enemas that I've seen before include "See man (anag) - medical procedures" , "Bowel evacuation producers" .)