Total loss of hope (7)
I believe the answer is:
despair
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">total loss of hope</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for despair that I've seen before include "Lose heart" , "Give up hope" , "The feeling that nothing will turn out well" , "Opposite of 10" , "A spider (anag.)" .)