Travel to ancient city with one manuscript from the East (7)
I believe the answer is:
tourism
'travel' is the definition.
(travelling to different places)
'to ancient city with one manuscript from the east' is the wordplay.
'ancient city' becomes 'ur' (ancient Sumerian city state).
'with' means one lot of letters go next to another.
'one' becomes 'i' (Roman numeral).
'manuscript' becomes 'ms' (abbreviation for manuscript).
'from the east' shows that the letters should be reversed in order (on a map from right to left).
'ms' in reverse letter order is 'sm'.
'to'+'ur'+'i'+'sm'='TOURISM'
(Other definitions for tourism that I've seen before include "The business of providing services to visitors" , "going places" , "leave business?" , "Holiday visits" , "Industry involved in attracting and servicing visitors" .)