Trouble, afflict (3)
I believe the answer is:
ail
<span class="explanation-format__ClueExplanation">I believe this is a double definition.<br/ ><br/ >'<span class="explanation-format__original">trouble</span>' is the first definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >'<span class="explanation-format__original">afflict</span>' is the second definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ ></span>
(Other definitions for ail that I've seen before include "Afflict -- feel unwell" , "Go sick" , "upset" , "Be unwell, suffer" , "Become sick" .)