US political strategist, male, even more sick (6)
I believe the answer is:
miller
'us political strategist male' is the definition.
I can't judge whether this defines the answer.
'even more sick' is the wordplay.
'even' becomes 'm' (I can't justify this - if you can you should believe this answer much more).
'more sick' becomes 'iller' ('ill' can be a synonym of 'sick').
'm'+'iller'='MILLER'
Can you help me to learn more?
(Other definitions for miller that I've seen before include "Arthur -, Death of a Salesman author" , "Cereal worker" , "US playwright who married Marilyn Monroe, d.2005" , "[PILGRIM in the CANTERBURY TALES]" , "A maker of flour" .)